Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD3 | Q9BZ95 | 5/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.68 |
| ▸ | PI4KA | P42356 | 4/20 | 0.68 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.68 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | NSD2 | O96028 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5465357 | 0.85 | HPGD (0.64) | NSD3HPGDLMNASMN1; SMN2MEN1 | |
| SCHEMBL3642511 | 0.84 | HPGD (0.62) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL11862441 | 0.83 | ADORA2A (0.60) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL21788552 | 0.83 | ADORA2A (0.76) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL29093669 | 0.83 | NSD3 (1.00) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL6659204 | 0.82 | ADORA2A (0.74) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL14441145 | 0.82 | HPGD (0.60) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| 9-Benzyl-9H-Adenine SCHEMBL104932 | 0.81 | ADORA2A (1.00) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1980131 | 0.81 | ADORA2A (0.68) | NSD3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL13268696 | 0.80 | ADORA2A (0.56) | NSD3ADORA2API4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENRIFIQUE (CNRS) | 2011-06-30 | — | — | US | disclosed |
| EP-2297075-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009147217-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | TUBB4A, TUBA4A, TUBGCP4 | NSD3 3003/4885ADORA2A 4740/4885PI4KA 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.