Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HPN | P05981 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768036 | 0.80 | HPN (0.47) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL4765776 | 0.78 | ALDH1A1 (0.44) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL10923940 | 0.78 | PDE4B (0.53) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL4748711 | 0.72 | MAPT (0.57) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL17172464 | 0.70 | MAPT (0.57) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL6756946 | 0.70 | FGFR1 (0.50) | MAPTHPNMEN1KMT2AALDH1A1 | |
| SCHEMBL3970330 | 0.70 | ALDH1A1 (0.57) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL31739259 | 0.70 | ALDH1A1 (0.57) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL5328812 | 0.69 | HPN (0.58) | MAPTGAAHPNMEN1KMT2A | |
| SCHEMBL25250554 | 0.69 | HPN (0.54) | MAPTGAAHPNMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309565-B1 | HETEROCYCLIC MUTILIN ESTERS AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-04-09 | — | — | EP | disclosed |