Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | AOC1 | P19801 | 4/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25577644 | 0.82 | ADRA2B (0.49) | ADRA2BLOXL2AOC1AOC3MAPT | |
| SCHEMBL26037690 | 0.78 | ADRA2B (0.50) | ADRA2BMAPTGAATSHRMAPK1 | |
| SCHEMBL31175766 | 0.78 | ADRA2B (0.50) | ADRA2BMAPTGAATSHRMAPK1 | |
| SCHEMBL7215312 | 0.74 | ADRA2B (0.47) | ADRA2BLOXL2MAPTGAATSHR | |
| SCHEMBL4731181 | 0.70 | ROCK2 (0.36) | ADRA2BCYP3A4 | |
| SCHEMBL2882589 | 0.69 | ADRA2B (0.45) | ADRA2BMPO | |
| SCHEMBL26037444 | 0.68 | GAA (0.44) | ADRA2BMAPTGAATSHRMAPK1 | |
| SCHEMBL31175764 | 0.68 | CYP3A4 (0.52) | ADRA2BLOXL2MAPTGAATSHR | |
| SCHEMBL10718351 | 0.68 | CYP3A4 (0.52) | ADRA2BLOXL2MAPTGAATSHR | |
| SCHEMBL25318193 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046216-A1 | KINASE INHIBITORS AND USES THEREOF | METHYLGENE, INC. (CA) | 2008-04-24 | — | — | WO | disclosed |