Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | HRH1 | P35367 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210341 | 0.76 | KMT2A (0.45) | MAPT | |
| SCHEMBL26037690 | 0.75 | ADRA2B (0.50) | ADRA2BMAPTAKR1B1MAPK1GAA | |
| SCHEMBL31175766 | 0.75 | ADRA2B (0.50) | ADRA2BMAPTAKR1B1MAPK1GAA | |
| SCHEMBL14223271 | 0.74 | ADRA2B (0.49) | ADRA2BLOXL2MAPTMAPK1GAA | |
| SCHEMBL25577644 | 0.74 | ADRA2B (0.49) | ADRA2BLOXL2MAPTMAPK1GAA | |
| SCHEMBL5305737 | 0.73 | CYP2D6 (0.43) | CYP2D6HRH1KCNH2MAPK1GAA | |
| SCHEMBL6757761 | 0.72 | HSP90AA1 (0.36) | CYP2D6HRH1KCNH2HSP90AA1MAP4K4 | |
| SCHEMBL22263575 | 0.70 | CYP3A4 (0.39) | CYP2D6HRH1KCNH2HSP90AA1L3MBTL1 | |
| SCHEMBL1137040 | 0.70 | ADRA2B (0.48) | ADRA2BLOXL2 | |
| SCHEMBL21044403 | 0.69 | FEN1 (0.57) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617339-B1 | 5-Isoxazolyloxymethyl-3-((dihydroxypropanoyl)-4-tetrahydropyri dyl-3,5- difluorophenyl)oxazolidinone, or the phosphated derivative or its disodium salt; antibiotic with useful activity against Grampositive pathogens | SYNGENTA LIMITED (GB) | 2003-09-09 | — | — | US | disclosed |