Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 14/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 14/20 | 0.54 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.53 |
| ▸ | ITGAL | P20701 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196466 | 0.87 | KDM4E (0.67) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL14224477 | 0.86 | ITGB3 (0.60) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL14224259 | 0.85 | ITGB2 (0.60) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL14224260 | 0.82 | ITGB2 (0.62) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL1198576 | 0.81 | KDM4E (0.83) | KDM4EALDH1A1ITGB3ITGA2BMEN1 | |
| SCHEMBL1198783 | 0.80 | ITGB2 (0.71) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL4823135 | 0.80 | KDM4E (0.66) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL14196465 | 0.78 | ITGB2 (0.74) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL4822771 | 0.76 | MEN1 (0.63) | KDM4EALDH1A1ITGB3ITGA2BITGB2 | |
| SCHEMBL14224472 | 0.75 | RAB9A (0.47) | KDM4EALDH1A1ITGB3ITGA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |