Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.60 |
| ▸ | ITGA2B | P08514 | 15/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.51 |
| ▸ | ITGAL | P20701 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224472 | 0.89 | RAB9A (0.47) | ITGB3ITGA2BKDM4EALDH1A1MEN1 | |
| SCHEMBL14224259 | 0.88 | ITGB2 (0.60) | ITGB3ITGA2BKDM4EALDH1A1AR | |
| SCHEMBL14224255 | 0.86 | KDM4E (0.56) | ITGB3ITGA2BKDM4EALDH1A1AR | |
| SCHEMBL14224260 | 0.86 | ITGB2 (0.62) | ITGB3ITGA2BKDM4EALDH1A1AR | |
| SCHEMBL14224480 | 0.85 | MEN1 (0.72) | ITGB3ITGA2BKDM4EALDH1A1MEN1 | |
| SCHEMBL1198576 | 0.82 | KDM4E (0.83) | ITGB3ITGA2BKDM4EALDH1A1MEN1 | |
| SCHEMBL12995768 | 0.78 | ITGB3 (0.42) | ITGB3ITGA2BKDM4EALDH1A1 | |
| SCHEMBL12994974 | 0.78 | ITGB3 (0.42) | ITGB3ITGA2BKDM4EALDH1A1 | |
| SCHEMBL14224471 | 0.77 | AR (0.53) | ITGB3ITGA2BKDM4EALDH1A1AR | |
| SCHEMBL14224469 | 0.77 | ITGB2 (0.47) | ITGB3ITGA2BKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |