Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224477 | 0.89 | ITGB3 (0.60) | KDM4EALDH1A1ITGB3ITGA2BMEN1 | |
| SCHEMBL14224469 | 0.87 | ITGB2 (0.47) | RAB9AKDM4EALDH1A1ITGB3ITGA2B | |
| SCHEMBL4829071 | 0.81 | KDM4E (0.72) | RAB9AKDM4EALDH1A1ITGB3ITGA2B | |
| SCHEMBL14224480 | 0.78 | MEN1 (0.72) | RAB9AKDM4EALDH1A1ITGB3ITGA2B | |
| SCHEMBL14224259 | 0.77 | ITGB2 (0.60) | KDM4EALDH1A1ITGB3ITGA2BMEN1 | |
| SCHEMBL14224468 | 0.76 | KDM4E (0.47) | RAB9AKDM4EALDH1A1ITGB3ITGA2B | |
| SCHEMBL14224255 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1ITGB3ITGA2BMEN1 | |
| SCHEMBL14224260 | 0.75 | ITGB2 (0.62) | KDM4EALDH1A1ITGB3ITGA2BMEN1 | |
| SCHEMBL4829469 | 0.73 | ITGB2 (0.58) | RAB9AKDM4EALDH1A1ITGB3ITGA2B | |
| SCHEMBL12995768 | 0.71 | ITGB3 (0.42) | KDM4EALDH1A1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |