Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14371528 | 1.00 | CCR5 (0.54) | CCR5RORCKDM1AFUCA1ACHE | |
| SCHEMBL6903904 | 0.91 | SIGMAR1 (0.51) | CCR5RORCFUCA1ACHESIGMAR1 | |
| SCHEMBL17086700 | 0.89 | SLC18A3 (0.45) | CCR5RORCKDM1AACHESIGMAR1 | |
| SCHEMBL17086759 | 0.89 | SLC18A3 (0.45) | CCR5RORCKDM1AACHESIGMAR1 | |
| SCHEMBL6571278 | 0.87 | CCR5 (0.60) | CCR5RORCKDM1AFUCA1SIGMAR1 | |
| SCHEMBL10070008 | 0.85 | RORC (0.50) | CCR5RORCKDM1ADRD2DRD3 | |
| SCHEMBL13406114 | 0.85 | ACHE (0.58) | CCR5KDM1AACHESIGMAR1DRD2 | |
| SCHEMBL13406112 | 0.85 | ACHE (0.58) | CCR5KDM1AACHESIGMAR1DRD2 | |
| SCHEMBL10041956 | 0.85 | FUCA1 (0.60) | FUCA1ACHESIGMAR1MC4R | |
| SCHEMBL16080228 | 0.85 | FUCA1 (0.60) | FUCA1ACHESIGMAR1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351711-B2 | Tricyclic indanyls as integrin inhibitors | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2008-04-01 | — | — | US | disclosed |