SCHEMBL14224949

SCHEMBL14224949

CCOc1ccccc1NC(=O)C(=O)Nc1ccccc1C

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.66
RAB9A P51151 1/20 0.66
GAA P10253 2/20 0.65
KMT2A Q03164 5/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
CYP2C19 P33261 1/20 0.58
KDM4E B2RXH2 1/20 0.58
LMNA P02545 3/20 0.56
POLB P06746 2/20 0.56
MCL1 Q07820 1/20 0.56
KCNH2 Q12809 1/20 0.55
MAPT P10636 1/20 0.55
TSHR P16473 2/20 0.55
ALDH1A1 P00352 2/20 0.55
MEN1 O00255 2/20 0.55
EGFR P00533 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
ALOX12 P18054 1/20 0.54
HTT P42858 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8110954 0.92 GAA (0.75) NPC1RAB9AGAAKMT2AL3MBTL1
SCHEMBL11005738 0.91 KMT2A (0.66) NPC1RAB9AGAAKMT2AL3MBTL1
SCHEMBL9408833 0.86 GAA (0.67) NPC1GAAKMT2AL3MBTL1CYP2C19
SCHEMBL9500928 0.84 GAA (0.65) NPC1RAB9AGAAKMT2AL3MBTL1
SCHEMBL30612660 0.84 GAA (0.65) NPC1GAAKMT2AL3MBTL1CYP2C19
SCHEMBL820418 0.84 GAA (0.65) NPC1GAAKMT2AL3MBTL1CYP2C19
SCHEMBL31442935 0.84 GAA (0.65) NPC1GAAKMT2AL3MBTL1CYP2C19
SCHEMBL453995 0.84 GAA (0.65) NPC1RAB9AGAAKMT2AL3MBTL1
SCHEMBL8479168 0.84 GAA (0.65) NPC1RAB9AGAAKMT2AL3MBTL1
SCHEMBL29365765 0.84 GAA (0.65) NPC1RAB9AGAAKMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220017474-A1 Novel Polycyclic Compound EUTEC NEW MATERIALS TECHNOLOGY (SUZHOU) CO., LTD. (CN) 2022-01-20 US disclosed
US-20210095095-A1 LIGHT EMITTING ELEMENT RÖHM GMBH (DE) 2021-04-01 US disclosed
WO-2019145269-A1 LIGHT EMITTING ELEMENT EVONIK RÖHM GMBH (DE) 2019-08-01 WO disclosed
WO-2018033502-A1 ACRYLIC MATERIALS FOR USE IN AN ULTRAVIOLET LIGHT ENGINE EVONIK RÖHM GMBH (DE) 2018-02-22 WO disclosed
EP-2994201-B1 COMPOSITIONS WITH HIGH QUANTITIES OF UV STABILIZERS BASF SE (DE) 2017-12-20 EP disclosed
US-20120316274-A1 WEATHER RESISTANT VINYL CHLORIDE RESIN COMPOSITION ADEKA CORPORATION (JP) 2012-12-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220017474-A1 Novel Polycyclic Compound CUTA, DSG1, UACA NPC1 4142/4885RAB9A 3236/4885GAA 3423/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.