Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229345 | 0.90 | TP53 (0.36) | MMP3TP53CA1CA12CA9 | |
| SCHEMBL14229451 | 0.86 | CA1 (0.43) | TP53CA1CA12CA9CA2 | |
| SCHEMBL14229123 | 0.85 | CNR2 (0.40) | MMP3TP53TAS2R14CA1CA12 | |
| SCHEMBL14228928 | 0.83 | CNR2 (0.39) | MMP3TP53CA2 | |
| SCHEMBL14230126 | 0.83 | TP53 (0.36) | MMP3TP53TAS2R14CA1CA2 | |
| SCHEMBL14228930 | 0.81 | CNR2 (0.41) | MMP3TP53CA2 | |
| SCHEMBL13309413 | 0.80 | PER2 (0.38) | MMP3TP53TAS2R14CA1 | |
| SCHEMBL14229469 | 0.79 | MMP3 (0.36) | MMP3TP53TAS2R14TDP1 | |
| SCHEMBL14229686 | 0.79 | PIK3CD (0.35) | MMP3TP53 | |
| SCHEMBL14200217 | 0.79 | ESR2 (0.30) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |