Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229891 | 0.92 | LTB4R2 (0.40) | TAS1R3TAS1R1MEN1KMT2ALTB4R2 | |
| SCHEMBL14228962 | 0.90 | TRPM8 (0.39) | TAS1R3TAS1R1MEN1KMT2ALTB4R2 | |
| SCHEMBL14229924 | 0.87 | TAS1R3 (0.39) | TAS1R3TAS1R1MEN1KMT2ALTB4R2 | |
| SCHEMBL14200765 | 0.85 | TAS1R3 (0.36) | TAS1R3TAS1R1MEN1KMT2AUBE2M | |
| SCHEMBL14229282 | 0.84 | PSEN1 (0.46) | SMN1; SMN2 | |
| SCHEMBL14229289 | 0.84 | MEN1 (0.42) | TAS1R3TAS1R1MEN1KMT2AUBE2M | |
| SCHEMBL14229894 | 0.84 | RIPK1 (0.44) | MEN1KMT2ALTB4R2UBE2MDCUN1D1 | |
| SCHEMBL14228970 | 0.83 | SMN1; SMN2 (0.37) | TAS1R3TAS1R1MEN1KMT2ALTB4R2 | |
| SCHEMBL14229065 | 0.82 | LTB4R2 (0.38) | TAS1R3TAS1R1MEN1KMT2ALTB4R2 | |
| SCHEMBL14229512 | 0.82 | LDHA (0.45) | MEN1KMT2AL3MBTL1ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |