Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GPX4 | P36969 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229289 | 0.92 | MEN1 (0.42) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14229248 | 0.88 | MEN1 (0.43) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14201027 | 0.87 | ALDH1A1 (0.38) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14229226 | 0.86 | CTSB (0.40) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14229891 | 0.85 | LTB4R2 (0.40) | MEN1KMT2AALDH1A1LTB4R2CNR1 | |
| SCHEMBL14229398 | 0.84 | EPHX2 (0.50) | — | |
| SCHEMBL14228979 | 0.83 | TAS1R3 (0.41) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14229293 | 0.82 | HSP90AA1 (0.41) | RAB9AMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL14229216 | 0.80 | PSEN1 (0.44) | ALDH1A1LTB4R2TSHR | |
| SCHEMBL14228980 | 0.80 | RIPK1 (0.42) | MEN1KMT2AALDH1A1LTB4R2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |