Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 14/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14228990 | 0.91 | PSEN1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14229899 | 0.91 | P2RX7 (0.31) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14229078 | 0.88 | ALDH1A1 (0.31) | ALDH1A1HPGD | |
| SCHEMBL14201018 | 0.86 | PSEN1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14229739 | 0.84 | TP53 (0.31) | — | |
| SCHEMBL14229417 | 0.84 | TAS1R3 (0.31) | — | |
| SCHEMBL14200872 | 0.79 | MLYCD (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14543478 | 0.78 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14230174 | 0.78 | KDM4E (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14229211 | 0.77 | ALDH1A1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |