Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.43 |
| ▸ | GPX4 | P36969 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229132 | 0.91 | ALDH1A1 (0.49) | TAS1R3TAS1R1MEN1KMT2AALDH1A1 | |
| SCHEMBL14229029 | 0.90 | MEN1 (0.45) | TAS1R3TAS1R1MEN1KMT2AALDH1A1 | |
| SCHEMBL14229531 | 0.89 | TAS1R3 (0.47) | TAS1R3TAS1R1MEN1KMT2AALDH1A1 | |
| SCHEMBL14229221 | 0.85 | TP53 (0.35) | TAS1R3TAS1R1MEN1KMT2ATP53 | |
| SCHEMBL14200458 | 0.85 | TAS1R3 (0.42) | TAS1R3TAS1R1MEN1KMT2AALDH1A1 | |
| SCHEMBL14229231 | 0.85 | L3MBTL1 (0.40) | ALDH1A1RAB9ATP53NPC1SLC6A2 | |
| SCHEMBL14229349 | 0.85 | TP53 (0.40) | TP53TDP1MAPTTSHR | |
| SCHEMBL14229199 | 0.85 | ALDH1A1 (0.41) | ALDH1A1RAB9ATP53NPC1HPGD | |
| SCHEMBL14228935 | 0.84 | MEN1 (0.46) | TAS1R3TAS1R1MEN1KMT2AALDH1A1 | |
| SCHEMBL14229354 | 0.84 | TP53 (0.49) | MEN1KMT2AALDH1A1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |