Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229510 | 0.91 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL14230197 | 0.88 | MEN1 (0.33) | MEN1KMT2AHTR7LTB4R2 | |
| SCHEMBL14229554 | 0.87 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL14200885 | 0.87 | — | — | |
| SCHEMBL14229215 | 0.87 | ALDH1A1 (0.41) | MEN1KMT2A | |
| SCHEMBL14229738 | 0.87 | CYP1A2 (0.33) | MEN1KMT2AHTR7LTB4R2 | |
| SCHEMBL14229224 | 0.86 | LTB4R2 (0.33) | MEN1KMT2ALTB4R2 | |
| SCHEMBL14543555 | 0.85 | KMT2A (0.34) | MEN1KMT2A | |
| SCHEMBL14543615 | 0.85 | RIPK1 (0.31) | — | |
| SCHEMBL14229079 | 0.84 | POLB (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |