Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229559 | 0.91 | MAPK1 (0.36) | PTGS2SIGMAR1MAPK1L3MBTL1 | |
| SCHEMBL14229313 | 0.91 | PTGS2 (0.37) | PTGS2SIGMAR1TSHRMAPK1L3MBTL1 | |
| SCHEMBL14229004 | 0.85 | TAS1R3 (0.44) | TSHRTDP1HSD17B10 | |
| SCHEMBL14201150 | 0.85 | PTGS2 (0.35) | PTGS2SIGMAR1TSHRMAPK1L3MBTL1 | |
| SCHEMBL14229475 | 0.84 | ALDH1A1 (0.39) | — | |
| SCHEMBL14229349 | 0.83 | TP53 (0.40) | PTGS2SIGMAR1TSHRMAPK1L3MBTL1 | |
| SCHEMBL14230178 | 0.80 | RIPK1 (0.41) | PTGS2SIGMAR1 | |
| SCHEMBL14200447 | 0.80 | MAPK1 (0.36) | PTGS2SIGMAR1TSHRMAPK1L3MBTL1 | |
| SCHEMBL14201516 | 0.80 | EPHX1 (0.36) | PTGS2SIGMAR1TSHRMAPK1L3MBTL1 | |
| SCHEMBL14229086 | 0.78 | GAA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |