Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR5 | O14804 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230076 | 0.87 | THRB (0.46) | PPARGTHRATHRBRXRAIGF1R | |
| SCHEMBL14230054 | 0.84 | PPARG (0.53) | PPARGITGB3ITGAVTHRATHRB | |
| SCHEMBL14230043 | 0.82 | THRB (0.56) | PPARGITGB3ITGAVTHRATHRB | |
| SCHEMBL14230075 | 0.80 | ESR1 (0.52) | IGF1RALOX15MEN1KMT2ALTA4H | |
| SCHEMBL13886594 | 0.80 | TAAR1 (0.57) | ALOX15MEN1KMT2ATAAR5TAAR1 | |
| SCHEMBL15684887 | 0.78 | CARM1 (0.45) | TAAR1EPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL22311203 | 0.77 | PPARG (0.45) | PPARGITGB3ITGAVTHRATHRB | |
| SCHEMBL13886703 | 0.76 | CA2 (0.47) | KMT2AEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL17874460 | 0.76 | FFAR1 (0.64) | PPARGITGB3ITGAVTHRATHRB | |
| SCHEMBL22311194 | 0.76 | ST14 (0.66) | PPARGITGB3ITGAVTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355079-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-08 | — | — | US | disclosed |