Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.46 |
| ▸ | PCNA | P12004 | 6/20 | 0.46 |
| ▸ | THRA | P10827 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230053 | 0.87 | PPARG (0.39) | THRBPCNATHRAPPARGRXRA | |
| SCHEMBL14230044 | 0.86 | TAAR5 (0.51) | THRBPCNATHRAPOLBHIF1A | |
| SCHEMBL14230042 | 0.86 | PCNA (0.64) | THRBPCNATHRAPOLBHIF1A | |
| SCHEMBL13886595 | 0.80 | TAAR1 (0.56) | THRBPCNATHRAPOLBHIF1A | |
| SCHEMBL14230075 | 0.79 | ESR1 (0.52) | IGF1RALOX15MEN1KMT2AADRB2 | |
| SCHEMBL14575001 | 0.77 | THRB (0.54) | THRBPCNATHRAPOLBHIF1A | |
| SCHEMBL13886704 | 0.76 | CA2 (0.47) | THRBPCNATHRAPOLBHIF1A | |
| SCHEMBL14230065 | 0.74 | TAAR5 (0.68) | PCNAPPARG | |
| SCHEMBL15684799 | 0.74 | LTA4H (0.54) | PPARGSMN1; SMN2CYP1A2IGF1RALOX15 | |
| SCHEMBL14230070 | 0.73 | PCNA (0.62) | THRBPCNATHRAPOLBHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355079-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-08 | — | — | US | disclosed |