Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | BAX | Q07812 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | F13A1 | P00488 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15701213 | 0.88 | TMEM97 (0.61) | ESR1ESR2KMT2ATMEM97SIGMAR1 | |
| SCHEMBL15684799 | 0.83 | LTA4H (0.54) | LTA4HBCHEIGF1RALOX15 | |
| SCHEMBL12804316 | 0.82 | ESR1 (0.70) | ESR1ESR2MEN1KMT2ACALM1 | |
| SCHEMBL579569 | 0.81 | TMEM97 (0.78) | ESR1ESR2MEN1KMT2ACALM1 | |
| SCHEMBL14230053 | 0.80 | PPARG (0.39) | MEN1KMT2ALTA4HIGF1RALOX15 | |
| SCHEMBL14230065 | 0.80 | TAAR5 (0.68) | — | |
| SCHEMBL14230070 | 0.79 | PCNA (0.62) | — | |
| SCHEMBL14230076 | 0.79 | THRB (0.46) | MEN1KMT2AADRB2IGF1RALOX15 | |
| SCHEMBL15684887 | 0.79 | CARM1 (0.45) | ADRB1ADRB3LTA4HBCHE | |
| SCHEMBL15684990 | 0.77 | LTA4H (0.56) | MEN1KMT2ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355079-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-08 | — | — | US | disclosed |