Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.75 |
| ▸ | DRD1 | P21728 | 10/20 | 0.74 |
| ▸ | DRD2 | P14416 | 10/20 | 0.74 |
| ▸ | DRD5 | P21918 | 2/20 | 0.74 |
| ▸ | DRD3 | P35462 | 2/20 | 0.74 |
| ▸ | DRD4 | P21917 | 1/20 | 0.74 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14234709 | 1.00 | RAD52 (0.75) | RAD52DRD1DRD2DRD5DRD3 | |
| SCHEMBL16627062 | 0.92 | DRD2 (0.83) | RAD52DRD1DRD2DRD5DRD3 | |
| SCHEMBL13430574 | 0.92 | DRD2 (0.83) | RAD52DRD1DRD2DRD5DRD3 | |
| SCHEMBL16627009 | 0.92 | DRD2 (0.83) | RAD52DRD1DRD2DRD5DRD3 | |
| SCHEMBL14235135 | 0.91 | DRD1 (0.82) | RAD52DRD1DRD2DRD5DRD3 | |
| SCHEMBL22137420 | 0.91 | RAD52 (0.78) | RAD52DRD1DRD2DRD5DRD3 | |
| Xylopinine SCHEMBL24696331 | 0.86 | RAD52 (1.00) | RAD52DRD1DRD2DRD5DRD3 | |
| Xylopinine SCHEMBL30473255 | 0.86 | RAD52 (1.00) | RAD52DRD1DRD2DRD5DRD3 | |
| Xylopinine SCHEMBL9011855 | 0.86 | RAD52 (1.00) | RAD52DRD1DRD2DRD5DRD3 | |
| Xylopinine SCHEMBL29999174 | 0.86 | RAD52 (1.00) | RAD52DRD1DRD2DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9737517-B2 | Pharmaceutical use of hexahydro-dibenzo[a,g]quinolizine compounds | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-22 | — | — | US | disclosed |
| US-9737517-B2 | Pharmaceutical use of hexahydro-dibenzo[a,g]quinolizine compounds | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-22 | — | — | US | disclosed |
| US-20160193195-A1 | PHARMACEUTICAL USE OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUNDS | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-07-07 | — | — | US | disclosed |
| US-20160193195-A1 | PHARMACEUTICAL USE OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUNDS | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-07-07 | — | — | US | disclosed |
| US-9359372-B2 | Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-07 | — | — | US | disclosed |
| US-9359372-B2 | Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-07 | — | — | US | disclosed |
| EP-2992883-A1 | PHARMACEUTICAL USE OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUNDS | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2016-03-09 | — | — | EP | disclosed |
| US-20150210711-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INST MATERIA MEDICA (CN) | 2015-07-30 | — | — | US | disclosed |
| US-20150210711-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INST MATERIA MEDICA (CN) | 2015-07-30 | — | — | US | disclosed |
| US-20140088130-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2014-03-27 | — | — | US | disclosed |
| US-20140088130-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2014-03-27 | — | — | US | disclosed |
| US-20140088130-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2014-03-27 | — | — | US | disclosed |
| WO-2012163179-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国科学院上海药物研究所 (CN) | 2012-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088130-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | HTR5A, HTR1A, HTR2C | RAD52 3502/4885DRD1 27/4885DRD2 16/4885 |
| US-20160193195-A1 | PHARMACEUTICAL USE OF HEXAHYDRO-DIBENZO[A,G]QUINOLIZINE COMPOUNDS | BPHL, QDPR, NQO2 | RAD52 2471/4885DRD1 780/4885DRD2 1049/4885 |
| US-20150210711-A1 | HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF | HTR5A, HTR1A, HTR2C | RAD52 3502/4885DRD1 27/4885DRD2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.