Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214071 | 0.83 | TDP1 (0.44) | TDP1ALDH1A1HIF1AMAPTKDM4E | |
| SCHEMBL14214068 | 0.79 | TDP1 (0.38) | TDP1ALDH1A1HIF1AMAPTKDM4E | |
| SCHEMBL14235850 | 0.75 | HIF1A (0.42) | TDP1ALDH1A1HIF1AMAPTKDM4E | |
| SCHEMBL14235851 | 0.74 | HIF1A (0.43) | ALDH1A1HIF1AMAPTKDM4EGAA | |
| SCHEMBL14235849 | 0.73 | ALDH1A1 (0.42) | TDP1ALDH1A1HSD11B1GAAPOLB | |
| SCHEMBL12859306 | 0.71 | NTRK1 (0.40) | ALDH1A1HIF1AMAPTKDM4ELMNA | |
| SCHEMBL6365979 | 0.70 | ALDH1A1 (0.49) | TDP1ALDH1A1MAPTHSD11B1GAA | |
| SCHEMBL419987 | 0.69 | NPSR1 (0.59) | TDP1ALDH1A1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL30486812 | 0.69 | NPSR1 (0.59) | TDP1ALDH1A1HTTSMN1; SMN2NPSR1 | |
| SCHEMBL6372007 | 0.68 | HSD11B1 (0.48) | TDP1ALDH1A1MAPTHSD11B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329703-B2 | Pyrazole compounds | XTL BIOPHARMACEUTICALS LTD. (IL) | 2012-12-11 | — | — | US | disclosed |