Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14236263 | 0.79 | TDP1 (0.41) | TDP1ALDH1A1MAPTKDM4EHIF1A | |
| SCHEMBL14214072 | 0.79 | BACE1 (0.39) | TDP1ALDH1A1MAPTKDM4EHIF1A | |
| SCHEMBL14214069 | 0.76 | HSD11B1 (0.39) | TDP1ALDH1A1MAPTKDM4EHSD11B1 | |
| SCHEMBL14214071 | 0.76 | TDP1 (0.44) | TDP1ALDH1A1MAPTKDM4EHIF1A | |
| SCHEMBL13597747 | 0.73 | HSD17B10 (0.47) | TDP1ALDH1A1HPGDHTTSMN1; SMN2 | |
| SCHEMBL4209889 | 0.69 | ALDH1A1 (0.57) | TDP1ALDH1A1GAAHPGDHTT | |
| SCHEMBL6365979 | 0.66 | ALDH1A1 (0.49) | TDP1ALDH1A1MAPTHSD11B1GAA | |
| SCHEMBL4077290 | 0.66 | ALDH1A1 (0.41) | TDP1ALDH1A1MAPTKDM4EGAA | |
| SCHEMBL4080077 | 0.66 | GRM5 (0.36) | TDP1ALDH1A1MAPTHSD11B1PKM | |
| SCHEMBL6374348 | 0.64 | ALDH1A1 (0.54) | TDP1ALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130177529-A1 | Pyrazole Compounds | VIVOQUEST, INC. | 2013-07-11 | — | — | US | disclosed |
| US-20130177529-A1 | Pyrazole Compounds | VIVOQUEST, INC. | 2013-07-11 | — | — | US | disclosed |
| US-8329703-B2 | Pyrazole compounds | XTL BIOPHARMACEUTICALS LTD. (IL) | 2012-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130177529-A1 | Pyrazole Compounds | MAVS, EIF2AK2, ZC3HAV1 | TDP1 2276/4885ALDH1A1 1769/4885MAPT 3193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.