Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551215 | 0.93 | GPR119 (0.51) | GPR119NPBWR1MCHR1TBK1ALK | |
| SCHEMBL2546271 | 0.93 | GPR119 (0.51) | GPR119NPBWR1MCHR1TBK1ALK | |
| SCHEMBL2542770 | 0.92 | GPR119 (0.50) | GPR119NPBWR1MCHR1TBK1PDE4A | |
| SCHEMBL2544042 | 0.90 | GPR119 (0.53) | GPR119NPBWR1MCHR1TBK1ALK | |
| SCHEMBL14237483 | 0.85 | GPR119 (0.49) | GPR119NPBWR1MCHR1TBK1 | |
| SCHEMBL14237662 | 0.85 | GPR119 (0.51) | GPR119NPBWR1MCHR1MEN1USP2 | |
| SCHEMBL14237660 | 0.82 | JAK3 (0.36) | GPR119KMT2APDE4B | |
| SCHEMBL1550872 | 0.82 | NPBWR1 (0.50) | GPR119NPBWR1MCHR1MEN1USP2 | |
| SCHEMBL14237663 | 0.81 | GPR119 (0.61) | GPR119 | |
| SCHEMBL14237487 | 0.80 | GPR119 (0.45) | GPR119NPBWR1MCHR1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |