Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2540906 | 0.92 | GPR119 (0.45) | GPR119NPBWR1MCHR1SMN1; SMN2PDE4D | |
| SCHEMBL2539976 | 0.92 | GPR119 (0.46) | GPR119NPBWR1MCHR1SMN1; SMN2PDE4D | |
| SCHEMBL14237483 | 0.88 | GPR119 (0.49) | GPR119NPBWR1MCHR1 | |
| SCHEMBL2536248 | 0.87 | GPR119 (0.44) | GPR119NPBWR1MCHR1PDE4DHPGDS | |
| SCHEMBL1550872 | 0.85 | NPBWR1 (0.50) | GPR119NPBWR1MCHR1PDE4DPDE4B | |
| SCHEMBL14237444 | 0.85 | SMN1; SMN2 (0.47) | GPR119SMN1; SMN2PDE4DPDE4BPDE4A | |
| SCHEMBL14237663 | 0.83 | GPR119 (0.61) | GPR119 | |
| SCHEMBL2546607 | 0.81 | KMT2A (0.36) | SMN1; SMN2PDE4B | |
| SCHEMBL2542239 | 0.80 | GPR119 (0.48) | GPR119NPBWR1MCHR1KDM1A | |
| SCHEMBL14237467 | 0.80 | GPR119 (0.51) | GPR119NPBWR1MCHR1PDE4DPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |