Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14247290 | 0.79 | IRAK4 (0.39) | IRAK4PIK3CDPIK3CAPIK3CBALOX15 | |
| SCHEMBL14247511 | 0.76 | ALOX15 (0.53) | ALOX15MAPK1KMT2A | |
| SCHEMBL20641274 | 0.75 | AURKA (0.47) | ALOX5BRD4KMT2AMAP4K4HTR7 | |
| SCHEMBL14247207 | 0.73 | ALOX15 (0.47) | ALOX15MAPK1KMT2A | |
| SCHEMBL14247342 | 0.71 | BRD4 (0.47) | ALOX5BRD4ALOX15MAPK1KMT2A | |
| SCHEMBL14247233 | 0.70 | NPSR1 (0.46) | ALOX15MAPK1KMT2AHTR7HTR6 | |
| SCHEMBL14247641 | 0.70 | CNR2 (0.47) | BRD4 | |
| SCHEMBL14247880 | 0.70 | ALOX15 (0.33) | PIK3CDPIK3CAPIK3CBALOX15MAPK1 | |
| SCHEMBL14247546 | 0.70 | AAK1 (0.39) | BRD4PIK3CDPIK3CAPIK3CBALOX15 | |
| SCHEMBL14247586 | 0.68 | CCNC (0.43) | IRAK4PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |