Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14247524 | 0.82 | MAPT (0.47) | KMT2ASMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL14247511 | 0.79 | ALOX15 (0.53) | KMT2AMAPTALOX15MAPK1HTT | |
| SCHEMBL14247207 | 0.76 | ALOX15 (0.47) | KMT2AALOX15MAPK1 | |
| SCHEMBL14247826 | 0.75 | DHFR (0.46) | SMN1; SMN2MAPTNPC1TP53ALOX15 | |
| SCHEMBL25301636 | 0.73 | SOS1 (0.46) | KMT2ASOS1MAPTNPC1RAB9A | |
| SCHEMBL14247546 | 0.73 | AAK1 (0.39) | BRD4KMT2AALOX15MAPK1 | |
| SCHEMBL14247782 | 0.71 | NCF1 (0.46) | KMT2ASMN1; SMN2PDE10AMAPTALOX15 | |
| SCHEMBL14247181 | 0.71 | ALOX5 (0.37) | BRD4KMT2ASMN1; SMN2ALOX15MAPK1 | |
| SCHEMBL14247233 | 0.71 | NPSR1 (0.46) | KMT2AMAPTALOX15MAPK1 | |
| SCHEMBL14247363 | 0.71 | GABRA1 (0.52) | KMT2ASOS1HTTTNFCXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |