SCHEMBL1424813

SCHEMBL1424813

COC(=O)c1nc(C)c(F)c(N)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.42
KDM4E B2RXH2 8/20 0.40
SMN1; SMN2 Q16637 5/20 0.40
ALDH1A1 P00352 5/20 0.40
L3MBTL1 Q9Y468 3/20 0.40
PKM P14618 3/20 0.40
TDP1 Q9NUW8 1/20 0.39
RCE1 Q9Y256 1/20 0.38
MAPT P10636 3/20 0.38
ATM Q13315 2/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
HTT P42858 1/20 0.36
RAB9A P51151 2/20 0.36
HSD17B10 Q99714 2/20 0.36
KMT2A Q03164 1/20 0.36
NPC1 O15118 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29556415 0.87 NPSR1 (0.45) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL1424149 0.87 NPSR1 (0.45) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL18560104 0.83 ALDH1A1 (0.43) NPSR1KDM4EALDH1A1L3MBTL1TDP1
SCHEMBL11024814 0.83 NPSR1 (0.41) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL16776863 0.83 NPSR1 (0.46) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL11940150 0.81 TDP1 (0.38) KDM4EL3MBTL1PKMTDP1MAPT
SCHEMBL1424874 0.81 TDP1 (0.55) KDM4EALDH1A1L3MBTL1PKMTDP1
SCHEMBL16776812 0.81 NPSR1 (0.40) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL1424219 0.81 NPSR1 (0.44) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL18560074 0.81 NPSR1 (0.42) NPSR1KDM4ESMN1; SMN2ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1608624-B1 6-ALKYL OR ALKENYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2011-03-23 EP disclosed
US-7432227-B2 6-alkyl or alkenyl-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-10-07 US disclosed
EP-1608624-A2 6-ALKYL OR ALKENYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2005-12-28 EP disclosed
WO-2004089906-A2 6-ALKYL OR ALKENYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2004-10-21 WO disclosed
US-20040198608-A1 6-Alkyl or alkenyl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2004-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040198608-A1 6-Alkyl or alkenyl-4-aminopicolinates and their use as herbicides AADAC, AASDHPPT, AADAT NPSR1 2922/4885KDM4E 383/4885SMN1; SMN2 3798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.