Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255203 | 0.86 | KDM4E (0.44) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL14255197 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL14255508 | 0.85 | ABL1 (0.49) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL14255194 | 0.82 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL14255189 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL14255204 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL14255187 | 0.74 | KDM4E (0.57) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL2152502 | 0.73 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDNPSR1CFTR | |
| SCHEMBL14255190 | 0.72 | MEN1 (0.45) | KDM4EALDH1A1HPGDNPSR1NPC1 | |
| SCHEMBL1539120 | 0.71 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDNPSR1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1313725-B1 | TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORP (US) | 2007-04-11 | — | — | EP | disclosed |