Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255194 | 0.88 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL14255197 | 0.82 | KDM4E (0.48) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL14255204 | 0.81 | KDM4E (0.47) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL14255187 | 0.78 | KDM4E (0.57) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL14255504 | 0.78 | CHEK1 (0.44) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL2152969 | 0.77 | TSHR (0.54) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL9077944 | 0.75 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL9039057 | 0.72 | ALOX5 (0.48) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL14255198 | 0.72 | KDM4E (0.45) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL14255189 | 0.71 | KDM4E (0.53) | MEN1KMT2AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1313725-B1 | TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORP (US) | 2007-04-11 | — | — | EP | disclosed |