Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255204 | 0.86 | KDM4E (0.47) | KDM4ECHEK1ALDH1A1HPGDNPSR1 | |
| SCHEMBL14255198 | 0.86 | KDM4E (0.45) | KDM4EALDH1A1HPGDNPSR1MAPK1 | |
| SCHEMBL14255509 | 0.86 | CHEK1 (0.47) | KDM4ECHEK1L3MBTL1RAB9ANPC1 | |
| SCHEMBL14255194 | 0.81 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL14255189 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1HPGDNPSR1RAB9A | |
| SCHEMBL9125289 | 0.76 | PSMD14 (0.50) | KDM4EALDH1A1MAPK1RAB9ALMNA | |
| SCHEMBL14255197 | 0.75 | KDM4E (0.48) | KDM4EALDH1A1HPGDNPSR1MAPK1 | |
| SCHEMBL14255187 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1HPGDNPSR1RAB9A | |
| SCHEMBL14255508 | 0.72 | ABL1 (0.49) | KDM4ECHEK1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL1071827 | 0.72 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1313725-B1 | TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORP (US) | 2007-04-11 | — | — | EP | disclosed |