Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14264666 | 0.75 | PLAT (0.53) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL9869931 | 0.68 | KDM4E (0.75) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL24589995 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL8226808 | 0.67 | KDM4E (0.49) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL9468353 | 0.66 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL10695931 | 0.66 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL3162634 | 0.65 | KDM4E (0.72) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL30579799 | 0.65 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL5804188 | 0.65 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPK1GLA | |
| SCHEMBL9468711 | 0.65 | KDM4E (0.71) | KDM4EALDH1A1HPGDMAPK1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058351-A1 | Deuterated pyrazolo(1,5-a)pyrimidine compounds; sedative or hypnotic agents; sleep disorders such as insomnia; modulating a GABA receptor-chloride ionophore complex in a cell through binding to the neurosteroid site on the complex | CONCERT PHARMACEUTICALS INC. (US) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058351-A1 | Deuterated pyrazolo(1,5-a)pyrimidine compounds; sedative or hypnotic agents; sleep disorders such as insomnia; modulating a GABA receptor-chloride ionophore complex in a cell through binding to the neurosteroid site on the complex | GABRA5, GABRA1, GABRA4 | KDM4E 2844/4885ALDH1A1 1696/4885HPGD 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.