Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6304715 | 0.80 | SMO (0.40) | AGTR1AGTR2TBXA2RF2TP53 | |
| SCHEMBL5109494 | 0.78 | TBXA2R (0.38) | AGTR1AGTR2TBXA2RF2 | |
| SCHEMBL6634370 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2TP53ALDH1A1PKM | |
| SCHEMBL5109574 | 0.70 | AGTR1 (0.42) | AGTR1AGTR2GRM5TBXA2RTP53 | |
| SCHEMBL6297873 | 0.69 | BCHE (0.35) | SMN1; SMN2TP53ALDH1A1PKM | |
| SCHEMBL7447330 | 0.68 | AGTR1 (0.48) | AGTR1AGTR2TP53ALDH1A1PKM | |
| SCHEMBL6304622 | 0.68 | MC4R (0.43) | SMN1; SMN2 | |
| SCHEMBL3064551 | 0.67 | GRM5 (0.41) | AGTR1AGTR2GRM5 | |
| SCHEMBL7218207 | 0.65 | CES2 (0.55) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7508681 | 0.64 | KMT2A (0.57) | GRM5PPARGPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348326-B2 | Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAa receptors | NEUROGEN CORPORATION (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348326-B2 | Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAa receptors | NEUROGEN CORPORATION (US) | 2008-03-25 | — | — | US | disclosed |