Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | RAF1 | P04049 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276217 | 0.82 | RAF1 (0.40) | BRAFRAF1KDRHTTIRAK4 | |
| SCHEMBL14276219 | 0.80 | KDR (0.42) | BRAFRAF1KDRHTTIRAK4 | |
| SCHEMBL14276234 | 0.80 | MAPK1 (0.40) | BRAFRAF1KDRIRAK4FLT3 | |
| SCHEMBL5118461 | 0.79 | TBXAS1 (0.46) | HTTALDH1A1TBXAS1 | |
| SCHEMBL14276227 | 0.79 | GSK3A (0.44) | — | |
| SCHEMBL14276145 | 0.73 | NR1I2 (0.46) | BRAFHTTALDH1A1 | |
| SCHEMBL5954423 | 0.70 | ALDH1A1 (0.46) | HTTALDH1A1ALOX15MAPK1HSD17B10 | |
| SCHEMBL14276225 | 0.69 | MAPK14 (0.49) | — | |
| SCHEMBL5682646 | 0.69 | GSK3A (0.46) | — | |
| SCHEMBL5114171 | 0.67 | TBXAS1 (0.39) | KDRALDH1A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |