Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280460 | 0.89 | PTGS2 (0.60) | PTGS2PTGS1ABCB11ALDH1A1CYP3A4 | |
| SCHEMBL13627353 | 0.81 | PTGS2 (0.66) | PTGS2PTGS1ABCB11ALDH1A1SMN1; SMN2 | |
| SCHEMBL8292457 | 0.80 | PTGS2 (0.71) | PTGS2PTGS1ALDH1A1RPA1SMN1; SMN2 | |
| SCHEMBL5698586 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1RPA1SMN1; SMN2CYP1A2 | |
| SCHEMBL27584983 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1RPA1SMN1; SMN2MEN1 | |
| SCHEMBL5698729 | 0.75 | PTGS2 (0.67) | PTGS2PTGS1ALDH1A1RPA1SMN1; SMN2 | |
| SCHEMBL212658 | 0.75 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL6339240 | 0.75 | PTGS2 (1.00) | PTGS2PTGS1ABCB11ALDH1A1 | |
| Sulfamide SCHEMBL7159984 | 0.74 | PTGS2 (0.76) | PTGS2PTGS1ABCB11ALDH1A1MEN1 | |
| SCHEMBL8635509 | 0.73 | PTGS2 (0.78) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320996-B2 | Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer | SUGEN, INC (US) | 2008-01-22 | — | — | US | disclosed |