Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28859839 | 0.80 | NAMPT (0.43) | MEN1KMT2ASMN1; SMN2HTTPARP1 | |
| SCHEMBL6762655 | 0.79 | RAB9A (0.68) | RAB9AMEN1KMT2ANPC1HDAC1 | |
| SCHEMBL27351272 | 0.76 | MEN1 (0.58) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL1308891 | 0.75 | RAB9A (0.59) | RAB9AMEN1KMT2ANPC1HDAC1 | |
| SCHEMBL15165560 | 0.75 | HPGD (0.65) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL4783765 | 0.75 | SMN1; SMN2 (0.54) | RAB9AMEN1KMT2ANPC1HDAC1 | |
| SCHEMBL13626447 | 0.73 | KCNK3 (0.55) | RAB9AMEN1KMT2ANPC1HDAC1 | |
| SCHEMBL1307853 | 0.73 | MEN1 (0.62) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31228747 | 0.72 | PTPN1 (0.58) | RAB9AMEN1KMT2ANPC1HDAC1 | |
| SCHEMBL6954756 | 0.72 | PTPN1 (0.58) | RAB9AMEN1KMT2ANPC1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660487-B1 | PYRROLE COMPOSITIONS USEFUL AS INHIBITORS OF C-MET | VERTEX PHARMA (US) | 2008-03-19 | — | — | EP | disclosed |
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314885-B2 | Pyrrole compounds useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-01-01 | — | — | US | disclosed |