Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12666627 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2POLBNPC1RAB9AALDH1A1 | |
| SCHEMBL6170575 | 0.81 | POLB (0.67) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL30008296 | 0.81 | POLB (0.67) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL13626447 | 0.78 | KCNK3 (0.55) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL15165560 | 0.77 | HPGD (0.65) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL29768498 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL9188407 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL28634418 | 0.76 | ALDH1A1 (0.75) | SMN1; SMN2NPC1RAB9AHTTALDH1A1 | |
| SCHEMBL2307853 | 0.76 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EPOLBNPC1RAB9A | |
| SCHEMBL14278745 | 0.75 | RAB9A (0.50) | SMN1; SMN2POLBNPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |