SCHEMBL14280266

SCHEMBL14280266

CC(c1ccc(Cl)cc1)N1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(C(C)c1ccc(Cl)cc1)C3=O

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGES O14684 1/20 0.42
ADRB2 P07550 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
NPC1 O15118 1/20 0.38
USP2 O75604 1/20 0.38
RAB9A P51151 1/20 0.38
ATM Q13315 1/20 0.38
KEAP1 Q14145 1/20 0.38
NFE2L2 Q16236 1/20 0.38
HSD11B1 P28845 4/20 0.38
ANXA2 P07355 1/20 0.35
S100A10 P60903 1/20 0.35
MDM2 Q00987 3/20 0.35
ABCB1 P08183 1/20 0.34
APAF1 O14727 1/20 0.34
POLB P06746 1/20 0.34
BRD4 O60885 1/20 0.34
FFAR2 O15552 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12845880 0.86 KMT2A (0.55) PTGESMEN1KMT2AMDM2
SCHEMBL12846303 0.86 KMT2A (0.55) PTGESMEN1KMT2AMDM2
SCHEMBL13878069 0.84 ALDH1A1 (0.41) PTGESNPC1RAB9AHSD11B1APAF1
SCHEMBL14280267 0.82 DNMT3A (0.42) KMT2ANPC1RAB9AHSD11B1APAF1
SCHEMBL14280257 0.82 MET (0.40) HSD11B1APAF1POLB
SCHEMBL14280264 0.82 POLB (0.55) KMT2ANPC1RAB9AAPAF1POLB
SCHEMBL13878053 0.81 ALDH1A1 (0.46) PTGESKMT2APOLB
SCHEMBL14280260 0.79 ALDH1A1 (0.45) KMT2AATMHSD11B1POLB
SCHEMBL23417382 0.79 MAPK1 (0.41) KMT2ANPC1RAB9AAPAF1POLB
SCHEMBL13923575 0.77 ALDH1A1 (0.43) PTGESKMT2AUSP2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080014520-A1 Organic photoreceptor for short wavelengths and electrophotographic imaging forming apparatus employing the organic photoreceptor SAMSUNG ELECTRONICS CO., LTD. 2008-01-17 US disclosed
US-20080014520-A1 Organic photoreceptor for short wavelengths and electrophotographic imaging forming apparatus employing the organic photoreceptor SAMSUNG ELECTRONICS CO., LTD. 2008-01-17 US disclosed
EP-1879076-A2 Organic photoreceptor for short wavelengths and electrophotographic imaging forming apparatus employing the organic photoreceptor Samsung Electronics Co., Ltd. (KR) 2008-01-16 EP disclosed
US-7314692-B2 Phenylazomethylene-cyclohexadienone derivatives comprising electron withdrawing group and electrophotographic photoreceptor comprising the derivatives SAMSUNG ELECTRONICS CO., LTD. (KR) 2008-01-01 US disclosed
US-7314692-B2 Phenylazomethylene-cyclohexadienone derivatives comprising electron withdrawing group and electrophotographic photoreceptor comprising the derivatives SAMSUNG ELECTRONICS CO., LTD. (KR) 2008-01-01 US disclosed