SCHEMBL14280366

SCHEMBL14280366

COc1ccc2c3ccc(OC)cc3n(-c3ccnc(-c4ccc(F)cc4F)c3)c2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.45
TGFBR1 P36897 3/20 0.41
DYRK1A Q13627 4/20 0.40
MAOA P21397 1/20 0.40
CHRNA7 P36544 1/20 0.39
METAP2 P50579 1/20 0.38
AMY1A P0DUB6 1/20 0.38
WNK1 Q9H4A3 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
HASPIN Q8TF76 2/20 0.37
FAAH O00519 1/20 0.37
MAPK13 O15264 1/20 0.37
MAPK12 P53778 1/20 0.37
MAPK11 Q15759 1/20 0.37
MAPK14 Q16539 1/20 0.37
CCR1 P32246 1/20 0.37
CCR5 P51681 1/20 0.37
CCR8 P51685 1/20 0.37
F2RL3 Q96RI0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3105471 0.80 MAPK14 (0.44) TRPA1TGFBR1METAP2NPC1RAB9A
SCHEMBL515651 0.79 CCR1 (0.59) TRPA1TGFBR1CHRNA7AMY1ANPC1
SCHEMBL29766750 0.69 CCR1 (0.55) METAP2FAAHCCR1CCR5CCR8
SCHEMBL16910413 0.69 CCR1 (0.55) METAP2FAAHCCR1CCR5CCR8
SCHEMBL503953 0.69 CCR1 (0.55) METAP2FAAHCCR1CCR5CCR8
SCHEMBL4864316 0.69 FAAH (0.46) TGFBR1NPC1RAB9AFAAHMAPK13
SCHEMBL13754820 0.69 GRM5 (0.40) TGFBR1MAOAMAPK13MAPK12MAPK11
SCHEMBL29445848 0.69 KMO (0.54) TRPA1TGFBR1NPC1RAB9AFAAH
SCHEMBL19072696 0.69 KMO (0.54) TRPA1TGFBR1NPC1RAB9AFAAH
SCHEMBL12988516 0.69 NPC1 (0.51) CHRNA7METAP2AMY1ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7320835-B2 Phosphorescent material E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-01-22 US disclosed
US-7320835-B2 Phosphorescent material E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-01-22 US disclosed