SCHEMBL14280908

SCHEMBL14280908

CCC(C)c1c(Cl)nc2c(C(C)O)cnn2c1NC(C)C(F)(F)F

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.32
GBA1 P04062 1/20 0.32
KMT2A Q03164 1/20 0.32
CDK7 P50613 1/20 0.31
CDK2 P24941 1/20 0.30
CDK9 P50750 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14280906 0.89
SCHEMBL13606365 0.87 GBA1 (0.40) MEN1GBA1KMT2A
SCHEMBL4874084 0.86 GBA1 (0.39) MEN1GBA1KMT2A
SCHEMBL13606364 0.85 KDM4E (0.40) MEN1GBA1KMT2ACDK2
SCHEMBL4873071 0.83 CDK2 (0.47) KMT2ACDK2
SCHEMBL4866649 0.83
SCHEMBL14280903 0.79
SCHEMBL4869992 0.76 KCNN3 (0.37) CDK9
SCHEMBL14587892 0.73 SCN5A (0.34)
SCHEMBL13606367 0.72 GBA1 (0.40) MEN1GBA1KMT2ACDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080021045-A1 7-Amino-5-Halopyrazolopyrimidines with a Fungicidal Action BAYER CROPSCIENCE AKTIENGESELLSCHSFT (DE) 2008-01-24 US disclosed
US-20080021045-A1 7-Amino-5-Halopyrazolopyrimidines with a Fungicidal Action BAYER CROPSCIENCE AKTIENGESELLSCHSFT (DE) 2008-01-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080021045-A1 7-Amino-5-Halopyrazolopyrimidines with a Fungicidal Action Q6ZSR9, CYP3A7, CYP4X1 MEN1 4357/4885GBA1 1802/4885KMT2A 1970/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.