Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13408206 | 0.87 | TBK1 (0.42) | TBK1 | |
| SCHEMBL14283774 | 0.85 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3R1PIK3CBMYLK4 | |
| SCHEMBL3610963 | 0.83 | TBK1 (0.44) | TBK1 | |
| SCHEMBL14283752 | 0.77 | PIK3CA (0.39) | PIK3CAPIK3CDPIK3R1PIK3CBMAP3K12 | |
| SCHEMBL13408194 | 0.75 | TBK1 (0.41) | PIK3CAPIK3CDPIK3R1PIK3CBMYLK4 | |
| SCHEMBL13442016 | 0.75 | MYLK4 (0.36) | PIK3CAPIK3CDPIK3R1PIK3CBMYLK4 | |
| SCHEMBL14282926 | 0.75 | MAPT (0.39) | MYLK4STK17ACDC7FEN1MAPKAPK2 | |
| SCHEMBL14283797 | 0.74 | PIK3CA (0.39) | PIK3CAPIK3CDPIK3R1PIK3CBMYLK4 | |
| SCHEMBL13408186 | 0.71 | CDC7 (0.43) | PIK3CAPIK3CDPIK3R1PIK3CBMYLK4 | |
| SCHEMBL3610717 | 0.71 | PRKAB2 (0.40) | PIK3CAPIK3CDPIK3R1PIK3CBALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |