Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14288483 | 0.95 | HDAC1 (0.52) | HDAC1HDAC6LMNAKMT2ACHRM1 | |
| SCHEMBL6897257 | 0.82 | SIGMAR1 (0.54) | TBXAS1TBXA2RSIGMAR1 | |
| SCHEMBL6421667 | 0.79 | KMT2A (0.50) | HDAC1HDAC6LMNAKMT2ACHRM1 | |
| SCHEMBL6421671 | 0.79 | KMT2A (0.50) | HDAC1HDAC6LMNAKMT2ACHRM1 | |
| SCHEMBL16540050 | 0.78 | KMT2A (0.49) | HDAC1HDAC6LMNAKMT2ACHRM1 | |
| SCHEMBL16540048 | 0.78 | KMT2A (0.49) | HDAC1HDAC6LMNAKMT2ACHRM1 | |
| SCHEMBL8094515 | 0.77 | SIGMAR1 (0.53) | TBXAS1TBXA2RSIGMAR1 | |
| SCHEMBL22660166 | 0.77 | KMT2A (0.55) | LMNAKMT2ACHRM1ADRA2BSLC6A4 | |
| SCHEMBL8835105 | 0.76 | LMNA (0.44) | HDAC1HDAC6LMNAKMT2ACHRM1 | |
| SCHEMBL9530856 | 0.76 | TBXAS1 (0.72) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |