Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | UQCRB | P14927 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533091 | 0.88 | BRPF1 (0.52) | MAPTUQCRBHSD17B2MEN1LMNA | |
| SCHEMBL532836 | 0.83 | HSD17B2 (0.42) | MAPTTDP1UQCRBHSD17B2MEN1 | |
| SCHEMBL14288683 | 0.82 | RAD52 (0.53) | MAPTTDP1MEN1LMNAHTT | |
| SCHEMBL532776 | 0.80 | FFAR4 (0.54) | MAPTTDP1MEN1LMNAKMT2A | |
| SCHEMBL534077 | 0.78 | TSHR (0.47) | HSD11B1MAPTMEN1LMNAKMT2A | |
| SCHEMBL14288684 | 0.77 | ACLY (0.53) | — | |
| SCHEMBL533017 | 0.75 | FFAR4 (0.55) | MAPTTDP1MEN1LMNAKMT2A | |
| SCHEMBL10092382 | 0.74 | FFAR4 (0.53) | MAPTATMLMNAKMT2AFFAR4 | |
| SCHEMBL533666 | 0.73 | FFAR4 (0.56) | MAPTMEN1LMNAHTTKMT2A | |
| SCHEMBL533055 | 0.73 | ALDH1A1 (0.45) | MAPTTDP1MEN1KMT2AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |