Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNF4 | P78317 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225600 | 0.83 | L3MBTL1 (0.39) | RNF4TSHRKEAP1NFE2L2BCL2A1 | |
| SCHEMBL5702218 | 0.77 | RNF4 (0.51) | RNF4TSHRKEAP1NFE2L2BCL2A1 | |
| SCHEMBL15054523 | 0.77 | RNF4 (0.49) | RNF4TSHRKEAP1NFE2L2BCL2A1 | |
| SCHEMBL7044788 | 0.74 | TSHR (0.51) | RNF4TSHRKEAP1NFE2L2BCL2A1 | |
| SCHEMBL15054037 | 0.74 | LTB4R2 (0.50) | RNF4TSHRKEAP1NFE2L2BCL2A1 | |
| SCHEMBL17628547 | 0.73 | RNF4 (0.58) | RNF4TSHRKEAP1NFE2L2BCL2A1 | |
| SCHEMBL249712 | 0.73 | RNF4 (0.48) | RNF4TSHRBCL2A1TRPM8ALDH1A1 | |
| SCHEMBL7106756 | 0.71 | KEAP1 (0.55) | RNF4TSHRKEAP1NFE2L2KMT2A | |
| SCHEMBL1337080 | 0.71 | USP2 (0.60) | RNF4TSHRBCL2A1TRPM8ALDH1A1 | |
| SCHEMBL19036616 | 0.71 | TSHR (0.42) | RNF4TSHRKEAP1NFE2L2BCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300460-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2010030727-A1 | 3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-03-18 | — | — | WO | disclosed |
| WO-2009155042-A1 | 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |