Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305182 | 0.86 | L3MBTL1 (0.67) | L3MBTL1ALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11435540 | 0.81 | L3MBTL1 (0.71) | L3MBTL1ALDH1A1KMT2AMEN1LMNA | |
| Etaqualone SCHEMBL30726094 | 0.80 | ALDH1A1 (0.73) | L3MBTL1ALDH1A1KMT2ALMNAMAPT | |
| Etaqualone SCHEMBL29357362 | 0.80 | ALDH1A1 (0.73) | L3MBTL1ALDH1A1KMT2ALMNAMAPT | |
| Etaqualone SCHEMBL466318 | 0.80 | ALDH1A1 (0.73) | L3MBTL1ALDH1A1KMT2ALMNAMAPT | |
| Etaqualone SCHEMBL30726099 | 0.80 | ALDH1A1 (0.73) | L3MBTL1ALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL14447224 | 0.80 | L3MBTL1 (0.45) | L3MBTL1ALDH1A1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL4465299 | 0.79 | L3MBTL1 (0.79) | L3MBTL1ALDH1A1LMNAHIF1ATSHR | |
| SCHEMBL8242227 | 0.77 | NPC1 (0.70) | L3MBTL1ALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1129120 | 0.76 | ALDH1A1 (0.54) | L3MBTL1ALDH1A1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008013840-A2 | ERASTIN ANALOGS AND USES THEREOF | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-01-31 | — | — | WO | disclosed |
| US-20070161644-A1 | Erastin analogs and uses thereof | STOCKWELL BRENT R | 2007-07-12 | — | — | US | disclosed |
| US-20070161644-A1 | Erastin analogs and uses thereof | STOCKWELL BRENT R | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161644-A1 | Erastin analogs and uses thereof | ERAP2, ERAP1, ERAL1 | L3MBTL1 4245/4885ALDH1A1 1049/4885KMT2A 3738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.