Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 15/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14306164 | 0.91 | EIF4E (0.49) | EIF4EALDH1A1MEN1LMNAGAA | |
| SCHEMBL16404016 | 0.87 | EIF4E (0.52) | EIF4E | |
| SCHEMBL14306165 | 0.86 | ATP4A (0.49) | EIF4EALDH1A1MEN1LMNAGAA | |
| SCHEMBL16404001 | 0.81 | EIF4E (0.57) | EIF4EALDH1A1MEN1LMNAGAA | |
| SCHEMBL16404021 | 0.80 | THRB (0.47) | EIF4EMEN1MAPTKMT2A | |
| SCHEMBL14318314 | 0.80 | EIF4E (0.49) | EIF4E | |
| SCHEMBL14315416 | 0.79 | EIF4E (0.61) | EIF4EALDH1A1MEN1LMNAGAA | |
| SCHEMBL6199409 | 0.76 | ALDH1A1 (0.57) | EIF4EALDH1A1MEN1GAAMAPT | |
| SCHEMBL16404002 | 0.76 | MAPT (0.51) | EIF4EALDH1A1MEN1LMNAGAA | |
| SCHEMBL6199744 | 0.75 | EIF4E (0.55) | EIF4EALDH1A1MEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718290-B1 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | CLEVEXEL PHARMA (FR) | 2016-05-04 | — | — | EP | disclosed |
| EP-2718290-B1 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | CLEVEXEL PHARMA (FR) | 2016-05-04 | — | — | EP | disclosed |
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |
| WO-2012172438-A9 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2013-02-07 | — | — | WO | disclosed |
| WO-2012172438-A2 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-12-20 | — | — | WO | disclosed |