Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888022 | 0.91 | TSHR (0.57) | HPGDRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL12988856 | 0.86 | GABRA1 (0.72) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL31151793 | 0.83 | HPGD (0.65) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL8573730 | 0.83 | HPGD (0.65) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL109220 | 0.79 | HPGD (0.70) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL25859869 | 0.79 | HPGD (0.55) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL25859487 | 0.79 | HPGD (0.55) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL11629969 | 0.78 | ALDH1A1 (0.65) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL25745395 | 0.78 | ALDH1A1 (0.56) | HPGDRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL25745388 | 0.78 | ALDH1A1 (0.56) | HPGDRAB9ANPC1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015179-A1 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015179-A1 | Modulators of muscarinic receptors | CHRM3, CHRM5, CHRM2 | HPGD 1197/4885RAB9A 1944/4885NPC1 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.