Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 11/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312798 | 0.90 | HPGDS (0.42) | HPGDSMAPTGRIN2BCSNK1DWNT3A | |
| SCHEMBL14313255 | 0.88 | HPGDS (0.42) | HPGDSMAPTGRIN2BCSNK1DWNT3A | |
| SCHEMBL14313343 | 0.86 | HPGDS (0.44) | HPGDSGRIN1GRIN2BCSNK1DWNT3A | |
| SCHEMBL14313134 | 0.86 | HPGDS (0.41) | HPGDSGRIN2BCSNK1DWNT3A | |
| SCHEMBL14312407 | 0.85 | HPGDS (0.39) | HPGDSMAPTGRIN1GRIN2BCSNK1D | |
| SCHEMBL14313344 | 0.85 | HPGDS (0.40) | HPGDSMAPTCSNK1DWNT3A | |
| SCHEMBL14312696 | 0.85 | HPGDS (0.43) | HPGDSMAPTGRIN2BCSNK1DWNT3A | |
| SCHEMBL14313002 | 0.85 | HPGDS (0.41) | HPGDSCSNK1DWNT3AJAK2JAK1 | |
| SCHEMBL3220594 | 0.84 | HPGDS (0.52) | HPGDSMAPTGRIN1GRIN2BCSNK1D | |
| SCHEMBL14313171 | 0.84 | HPGDS (0.46) | HPGDSGRIN1GRIN2BCSNK1DWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |