Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | FOS | P01100 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313255 | 0.93 | HPGDS (0.42) | HPGDSCSNK1DHCRTR2WNT3APDGFRB | |
| SCHEMBL14312798 | 0.89 | HPGDS (0.42) | HPGDSCSNK1DHCRTR2WNT3APDGFRB | |
| SCHEMBL14312983 | 0.89 | HPGDS (0.40) | HPGDSFOSJUNNFKB1NFKB2 | |
| SCHEMBL14312743 | 0.88 | HPGDS (0.42) | HPGDS | |
| SCHEMBL14312738 | 0.87 | HPGDS (0.39) | HPGDSCSNK1DHCRTR2PSEN1PSEN2 | |
| SCHEMBL14312563 | 0.85 | HPGDS (0.41) | HPGDSCSNK1DWNT3AMAPT | |
| SCHEMBL3810374 | 0.85 | HPGDS (0.51) | HPGDSSLC6A2SLC6A4FOSJUN | |
| SCHEMBL14312696 | 0.84 | HPGDS (0.43) | HPGDSSLC6A2SLC6A4CSNK1DHCRTR2 | |
| SCHEMBL14313134 | 0.83 | HPGDS (0.41) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL14312670 | 0.83 | LMNA (0.39) | HPGDSLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |