Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 4/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313262 | 0.90 | HPGDS (0.42) | HPGDSCSNK1DWNT3APSEN1PSEN2 | |
| SCHEMBL14312798 | 0.87 | HPGDS (0.42) | HPGDSCSNK1DWNT3APSEN1PSEN2 | |
| SCHEMBL14313134 | 0.86 | HPGDS (0.41) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL14312890 | 0.86 | SLC22A12 (0.37) | HPGDSCSNK1DSLC22A12WNT3AJAK2 | |
| SCHEMBL14313255 | 0.85 | HPGDS (0.42) | HPGDSCSNK1DWNT3APSEN1PSEN2 | |
| SCHEMBL14312563 | 0.85 | HPGDS (0.41) | HPGDSCSNK1DWNT3AJAK2JAK1 | |
| SCHEMBL3221574 | 0.84 | HPGDS (0.53) | HPGDSCSNK1DSLC22A12WNT3AJAK2 | |
| SCHEMBL14313148 | 0.84 | HPGDS (0.43) | HPGDSCSNK1DWNT3APDGFRBPDGFRA | |
| SCHEMBL14312955 | 0.84 | HPGDS (0.42) | HPGDSCSNK1DWNT3APSEN1PSEN2 | |
| SCHEMBL14313197 | 0.83 | HPGDS (0.40) | HPGDSCSNK1DWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |