Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312748 | 0.93 | HPGDS (0.37) | HPGDSMAPTNPSR1POLBPTGDR2 | |
| SCHEMBL14313264 | 0.89 | HPGDS (0.38) | HPGDSHPGDPTGDR2S1PR1S1PR3 | |
| SCHEMBL14312982 | 0.89 | TGFBR1 (0.37) | HPGDSTGFBR1HPGDSCDKDM4E | |
| SCHEMBL14313324 | 0.88 | TGFBR1 (0.34) | HPGDSTGFBR1MAPTNPSR1HPGD | |
| SCHEMBL14313363 | 0.88 | HPGDS (0.47) | HPGDSMAPTNPSR1PTGDR2MEN1 | |
| SCHEMBL14312735 | 0.87 | TGFBR1 (0.35) | TGFBR1HPGDKDM4EALDH1A1TSHR | |
| SCHEMBL14312884 | 0.87 | HPGDS (0.39) | HPGDSTGFBR1NTRK1MAPTNPSR1 | |
| SCHEMBL14312847 | 0.86 | HPGDS (0.36) | HPGDSTGFBR1NTRK1MAPTNPSR1 | |
| SCHEMBL14312986 | 0.86 | TGFBR1 (0.35) | TGFBR1HPGDKDM4EALDH1A1TSHR | |
| SCHEMBL14313250 | 0.85 | HPGDS (0.37) | HPGDSTGFBR1NTRK1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142516-B1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI SA (FR) | 2012-12-26 | — | — | EP | claimed |